KINASE INHIBITOR SCREENING IDENTIFIES CYCLIN-DEPENDENT KINASES AND GLYCOGEN SYNTHASE KINASE 3 AS POTENTIAL MODULATORS OF TDP-43 CYTOSOLIC ACCUMULATION DURING CELL STRESS.

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD).It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subsequent accumulation, are controlled in these diseas

Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world.Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death.Reports on a dysregulated immune system in the sever

As the performance of a convolutional neural network is logarithmically proportional to the amount of training data, data augmentation has attracted increasing attention in recent years.Although the current data augmentation methods are efficient because they force the network to learn multiple parts of a given training image through occlusion or r

Before the origin of writing, oral literature was used by many African families to pass down values and impart knowledge and good morals from one generation to the other and to pass knowledge from one generation to the other.However, modern families hardly see value in narrating these folktales to their rk559 children as they claim that they have n

The subject of the study are the norms of penitentiary law governing the recognition of the convict as a repeat infringer of the established service order and the legal consequences of this legal fact.The paper discusses the implementation of the problematic aspects of the legal consequences of recognizing the convict as a repeat infringer of the e